proton pump inhibitors (PPIs) might DECREASE the efficacy of clopidogrel (Plavix)

April 2009

There's growing concern that proton pump inhibitors (PPIs) might DECREASE the efficacy of clopidogrel (Plavix).

At first many experts dismissed this because it was based on in vitro platelet aggregation studies...not clinical outcomes.

Now some new studies suggest that patients taking clopidogrel plus a PPI actually have more cardiovascular events.

Get concise advice on drug therapy, plus unlimited access to CE

Pharmacist's Letter includes:

12 issues every year, with brief articles about new meds and hot topics
200+ CE courses, including the popular CE-in-the-Letter
Quick reference drug comparison charts
Access to the entire archive

Subscribe Today!

Already a subscriber? Log in

Volume pricing available. Get a quote

Table of Contents

proton pump inhibitors (PPIs) might DECREASE the efficacy of clopidogrel (Plavix)
Shortages alternatives to oxycodone
Cardiology whether it's HARMFUL to combine an ACE inhibitor and ARB
Respiratory & Allergy Symbicort (budesonide/formoterol) will be used more for COPD
Respiratory & Allergy patients on Afrin or other nasal decongestants get rebound congestion
Pediatrics Miralax is being used more to treat constipation in kids
Psychiatry how to treat dementia associated with Parkinson's
Psychiatry metabolic acidosis in patients taking the antiepileptic, zonisamide (Zonegran, etc)
Antithrombotics when and how to use vitamin K to reverse the effects of warfarin
Gastroenterology Metoclopramide will have a new MedGuide and black box warning about the risk for tardive dyskinesia
Diabetes controversy about using glyburide for type 2 diabetes
Practice How should you handle an Rx written for the prescriber's personal or family use
Gout Uloric (YOU-lor-ik, febuxostat) is the first new chronic treatment for gout in over 40 years